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Abstract
Extract
Sudden death after routine dosing of dogs with the anthelmintic, bunamidine, is probably due to the onset of ventricular fibrillation (Fastier et al., Citation1968). However, it has not proved possible to discover conditions under which ventricular fibrillation can be obtained consistently in dogs by treatment with bunamidine and adrenaline. This makes it difficult to test in dogs what was thought would be a reasonable prophylactic measure, namely, administration of a beta-blocker. Treatment with such beta-blockers as propranolol has been found to reduce substantially the occurrence of ventricular arrhythmias in circumstances where sympathetic activity plays an important part in the initiation of the disorder (Lucchesi and Whitsitt, Citation1969; Dollery et al, Citation1969).