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Abstract
Extract
After a drug has entered the bloodstream it is distributed throughout the body in the water phase of plasma. Kinetics of the distribution and elimination of the majority of drugs may be accurately described by considering the body to be a two-compartment open model (Nelson, Citation1961; Notari, Citation1971). The principles of drug distribution were reviewed in another article (Baggot, Citation1974). A drug administered intravenously will undergo simultaneous distribution and elimination processes. The drug disappearance rate from plasma during the initial phase is fast and related both to the extent of distribution and to the efficiency of elimination mechanisms.