The anthelmintic efficacy of mebendazole against adult Fasciola hepatica and a concurrent mixed nematode infection in sheep

Abstract

Extract

Delak et al. (1965) reported that thiabendazole in combination with hexachlorophene (163 to 254 mg/kg thiabendazole; 16.3 to 25.4 mg/kg hexachlorophene) was effective in removing adult Fasciola hepatica from infected sheep. This would appear to be the only record of a benzimidazole derivative; having significant anthelmintic activity against F. hepatica. It is interesting to note, however, that a related trematode, Dicrocoelium dendriticum (the lancet fluke), can be eliminated from infected sheep by thiabendazole alone, at a dose rate of 500 mg/kg (Guilhon, 1965).