Use of a synthetic prostaglandin analogue for synchronization of oestrus in heifers

Abstract

Extract

Following the initial report of synchronization of oestrus by intra-uterine infusion of prostaglandin F_2α (PGF_2α; Rowson et al, 1972), a large amount of data has been published on the effects of dose rate and route of administration of PGF_2α on the effectiveness of oestrus synchronization. The most convenient method of administration is the intramuscular route; however, owing to the rapidrate of metabolism of PGF_2α (Piper et al., 1970) very large doses are needed to achieve consistent effects. The recent development of potent synthetic analogues of prostaglandin has further stimulated research on oestrus control by this method of administration (Tervit et al., 1973; Cooper, 1974; Nancarrow and Hearnshaw, 1974).