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Scientific Article

Leptospira interrogans serotype pomona infection in pigs: prevention of leptospiruria by immunisation before exposure to a natural infection

Pages 33-35 | Received 13 Apr 1976, Published online: 23 Feb 2011
 

Summary

Fourteen of 24 pigs were immunised with repeated injections of killed cultures of Leptospira serotype pomona administered over a three-week period. The remaining 10 pigs served as controls.

Five days after immunisation all pigs were exposed to the same natural infection by being housed together for 12 weeks in a pen which received effluent from other pens containing infected pigs.

Neither leptospiruria nor kidney lesions were detected in any of the immunised pigs. In contrast, leptospiruria and kidney lesions occurred in all the controls.

The development of serum agglutinins after immunisation and before exposure suggested that this could be used as an index of adequate antigenic stimulation.

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