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Abstract
The avermectins are macrocyclic lactones with exceptional potency and spectrum of activity against nematode and arthropod parasites. They are produced by a new species of actinomycete, Streptomyces avermitilis. They are active when given orally or parenterally, at dosages of a fraction of a milligram per kilogram, against many immature and mature nematode and arthropod parasites of sheep, cattle, dogs, horses and swine. The avermectins appear to paralyze nematodes and arthropods by potentiating the presynaptic release of gamma-aminobutyric acid, thereby blocking post-synaptic transmission of nerve impulses. A chemically modified derivative, 22,23-dihydroavermectin B1, known generically as ivermectin, has been selected for development.