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Clinical Communication

Splenic mast cell tumour and mastocytaemia in a cat: case study and literature review

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Pages 117-121 | Accepted 02 May 2000, Published online: 22 Feb 2011
 

Abstract

Case: An 11-year-old female domestic shorthaired cat presenting with clinical signs of depression, anorexia, weight loss, fever, anaemia and a mid-abdominal mass was referred for abdominal ultrasound examination.

Clinical findings: Ultrasonography of the abdomen identified a markedly enlarged spleen. Ultrasound-guided fine- needle aspiration biopsy of the spleen revealed a uniform population of mast cells, 11% of which were observed to have phagocytosed erythrocytes. It is speculated that this may have been a contributing factor in the development of anaemia in this case. Mast cells were detected in a peripheral-blood smear and a diagnosis of systemic mastocytosis (splenic mast cell tumour together with mastocytaemia) was made. This diagnosis was subsequently confirmed by histopathology of the spleen.

Conclusion: Splenectomy and treatment with corticosteroids appears to have resulted in remission of clinical signs and anaemia. A reduction in the concentration of mast cells in the peripheral blood had not occurred 6 weeks post- splenectomy, but was evident by 10 months post-splenectomy.

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