Mannosidosis in cattle and its control

Abstract

Extract

The New Zealand mannosidosis control scheme, based on testing for heterozygous individuals, was the first inherited disease-control programme implemented in a national population of animals to be reported (Jolly 1978). Initiated in 1972 and completed in 1982, it has effectively controlled the economically important lysosomal storage disease of cattle known as mannosidosis. The disease was also studied in depth as a model of analogous human diseases and contributed significantly to present knowledge of glycobiology (Daniel et al 1989; Jolly et al 1989) and other lysosomal storage diseases (Jolly and Walkley 1997).