Failure of acid secretion during infection of the ovine abomasum by the nematode parasite Teladorsagia circumcincta

Abstract

Elevation of the abomasal pH of ruminants is a well known consequence of nematode parasitism. Many have argued that the nematodes seek to increase pH to promote their survival. Indeed, there is limited evidence that substances released by the parasites are capable of directly influencing parietal cell activity. In one experimental series, excretions/secretions (ES) of Teladorsagia circumcincta reduced the apparent activity of rabbit gastric glands. Worm ES were shown to contain ammonia, probably accounting for the observed activity, and the effects of ES/ammonia are almost certainly an in-vitro phenomenon only. An alternative hypothesis contends that the loss of acid secretion arises as a consequence of the profound host response elicited by the presence of the parasites. Invariably, presence of parasites is accompanied by an inflammatory response in which eosinophils are conspicuous. Recent research has shown that exudates from inflamed tissues were also inhibitory to gastric gland activity and that during infection, expression of the pro-inflammatory cytokine interleukin 1-beta, the most potent known inhibitor of acid secretion by parietal cells, was increased. Further, the elevation of abomasal pH may prove to have adverse effects on the ability of the parasites to maintain their position within the abomasum.