Investigation of fetal loss in ewe lambs in relation to liveweight changes and progesterone concentrations in early to mid gestation

Abstract

AIMS: To investigate associations between changes in liveweight and fetal loss in ewe lambs and to determine whether fetal loss was associated with concentrations of progesterone in early and mid-gestation.

METHODS: Ewe lambs on two commercial sheep farms (Flock A; n=504 and Flock B; n=460) in the southern North Island of New Zealand were weighed, and body condition score was assessed, prior to breeding and throughout pregnancy. Pregnancy diagnosis was undertaken approximately 56 (PD1), 80 (PD2) and 110 (PD3) days after the start of breeding and fetal loss determined. Blood samples were collected from a cohort of 407 ewe lambs between 45–54 and 73–84 days of gestation. Those that subsequently were diagnosed with fetal loss (n=16) were matched with ewe lambs that maintained pregnancy (n=16), and concentrations of progesterone were measured in the plasma samples from these animals.

RESULTS: Fetal loss was diagnosed in 55/472 (11.7%) pregnant ewes from Flock A and 14/378 (3.7%) from Flock B. In both flocks the change in conceptus-free liveweight (CFLW) between PD1 and PD2 differed between ewe lambs with and without fetal loss; in Flock A the mean change was −59.9 (95% CI=−80.1 to −39.7) g/day vs. −3.43 (95% CI=−9.8 to 3.0) g/day (p<0.001), and in Flock B the change was −38.5 (95% CI=−78.9 to 1.94) g/day vs. 79.5 (95% CI=72.6–86.4) g/day (p<0.001). Similarly in Flock A the mean increase in CFLW between PD2 and PD3 was lower in ewe lambs with fetal loss than in those that maintained pregnancy (25.8 (95% CI=−13.8 to 65.4) g/day vs. 181.9 (95% CI=175.1–188.7) g/day) (p<0.001). There was no difference (p>0.05) in early and mid-gestation mean concentrations of progesterone in plasma between ewe lambs that had fetal loss compared with those that maintained pregnancy.

CONCLUSIONS: Ewe lambs with fetal loss had a marked reduction in CFLW in the 24–30 days leading up to the identification of the fetal loss compared with those that maintained pregnancy. Early and mid-gestation concentrations of progesterone in plasma were similar between ewe lambs who went on to have fetal loss and those that maintained pregnancy.

KEY WORDS:

• Fetal loss
• pregnancy loss
• sheep
• reproduction
• progesterone
• live weight

Acknowledgements

Many thanks to the flock owners involved in this study and their veterinarians. Thanks to Geoff Purchas, Dean Burnham, Catriona Jenkinson and various students for their assistance. This study was funded by Beef and Lamb New Zealand.

Notes

*Non-peer-reviewed

Additional information

Funding

This work was supported by Beef and Lamb New Zealand, grant number 14MU09.