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Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 12
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Research Article

Metabolism of N-isopropylacetanilide in rat

, &
Pages 1153-1157 | Published online: 22 Sep 2008
 

Abstract

1. Radioactivity from oral doses of N-isopropyl[1-14C]acetanilide was excreted in urine (53.5%), faeces (8.1%) and expired air (17.0%) of rat. 2. Enterohepatic circulation occurred during formation of ∼ 34% of the metabolites. N-isopropylacetanilide was metabolized by oxidation in all moieties of the molecule with subsequent conjugation with glucuronic and sulphuric acids. 3. The sulphate ester of 4′-hydroxyacetanilide (acetaminophen) was the major metabolite (28% of the dose).

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