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Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 7
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Research Article

Metabolic activity of fresh and cryopreserved cynomolgus monkey (Macaca fascicularis) hepatocytes

N. J. Hewitt Institute of Toxicology, Merck KGaA, Frankfurterstrasse 250, D-64271 Darmstadt, Germany
,
T. Fischer Covance Laboratories GmbH, Kesselfeld 29, D-48163 Munster, Germany
,
U. Zuehlke Institute of Toxicology, University of Mainz, Obere Zahlbacher Strasse 67, D-55131, Mainz, Germany
,
F. Oesch Institute of Toxicology, Merck KGaA, Frankfurterstrasse 250, D-64271 Darmstadt, Germany
&
D. Utesch Covance Laboratories GmbH, Kesselfeld 29, D-48163 Munster, Germany
Pages 665-681 | Published online: 22 Sep 2008
 
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Abstract

1. The effect of cryopreservation on the metabolic capacity of monkey hepatocytes over 4 h in suspension and 24 h in culture was determined. Hepatocytes were diluted in a buffer containing 10% DMSO and frozen in a computer-controlled chamber. 2. Initial ethoxyresorufin and ethoxycoumarin O

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