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Xenobiotica
the fate of foreign compounds in biological systems
Volume 34, 2004 - Issue 7
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Research Article

Cross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequences

, , , , , , & show all
Pages 633-664 | Received 22 Mar 2004, Published online: 22 Sep 2008
 

Abstract

  1. Recent investigations on nuclear receptors and other transcription factors involved in the regulation of genes encoding xenobiotic metabolizing and transport systems reveal that xenobiotic-dependent signalling pathways are embedded in, and establish functional interactions with, a tangle of regulatory networks involving the glucocorticoid and oestrogen receptors, the hypoxia-inducible factor, the vitamin D receptor and other transcription factors/nuclear receptors controlling cholesterol/bile salt homeostasis and liver differentiation.

  2. Such functional interferences provide new insight, first for understanding how xenobiotics might exert adverse effects, and second how physiopathological stimuli affect xenobiotic metabolism.

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