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Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 12
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Original Article

In vivo metabolism of α-methyltryptamine in rats: Identification of urinary metabolites

, , , , &
Pages 1476-1486 | Received 23 May 2008, Accepted 19 Sep 2008, Published online: 21 Nov 2008
 

Abstract

1. The in vivo metabolism of α-methyltryptamine (AMT), a psychoactive tryptamine analogue, was studied in rats.

2. Male Wistar rats were administered 10 mg kg−1 AMT orally and 24-h urine fractions were collected. After enzymatic hydrolysis of the urine sample, the metabolites were extracted by liquid–liquid extraction and analysed by gas chromatography/mass spectrometry (GC/MS).

3. 2-Oxo-AMT, 6-hydroxy-AMT, 7-hydroxy-AMT and 1′-hydroxy-AMT were detected as metabolites of AMT.

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