Meeting report: 2nd workshop of the peptide ADME discussion group

Abstract

Challenges and opportunities within peptide ADME (absorption, distribution, metabolism and elimination) were presented and discussed at the 2nd workshop of the Peptide ADME Discussion Group in Cambridge, UK (17th of September 2019). This article summarises the presentations and discussions from this workshop.

The following topics were covered:

• Peptide drug-drug interactions (DDIs)

• Regulatory perspectives on peptide ADME studies

• Bioavailability of therapeutic peptides impacted by metabolism and oligomerization in the subcutaneous compartment

• Regulated bioanalysis of parent peptide and active metabolites by immunoaffinity LC-MS/MS

• Peptide radiopharmaceutical development

Keywords:

• Peptides
• ADME
• drug-drug interactions
• drug development

Acknowledgements

The authors would like to thank all speakers for their contributions.

Disclosure statement

No potential conflict of interest was reported by the author(s).