Abstract
Challenges within peptide and oligonucleotide ADME (absorption, distribution, metabolism and elimination) and scientific ideas on how to solve them were presented and discussed at the DMDG (Drug Metabolism and Discussion Group) Peptide and Oligonucleotide ADME Workshop 2022 (2nd and 3rd of October 2022). This meeting report summarises the presentations and discussions from this workshop.
The following topics were covered:
Overview of the drug modality landscape
Metabolism & modelling
Analytical challenges
Drug-drug interactions reports from industry working groups
Regulatory interactions
Acknowledgements
The organisers thank all speakers for their contributions, and to all participants for fruitful discussions. The authors acknowledge also the DMDG organising and technical team, in particular Stuart Hex and Chris Barron (AssociAction Enterprises), for support with organizing the workshop.
Disclosure statement
No potential conflict of interest was reported by the author(s).