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Xenobiotica
the fate of foreign compounds in biological systems
Volume 53, 2023 - Issue 4
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Minutes of meeting

Meeting report: DMDG peptide and oligonucleotide ADME workshop 2022

, , & ORCID Icon
Pages 332-337 | Received 17 May 2023, Accepted 07 Jun 2023, Published online: 19 Jun 2023
 

Abstract

Challenges within peptide and oligonucleotide ADME (absorption, distribution, metabolism and elimination) and scientific ideas on how to solve them were presented and discussed at the DMDG (Drug Metabolism and Discussion Group) Peptide and Oligonucleotide ADME Workshop 2022 (2nd and 3rd of October 2022). This meeting report summarises the presentations and discussions from this workshop.

The following topics were covered:

  • Overview of the drug modality landscape

  • Metabolism & modelling

  • Analytical challenges

  • Drug-drug interactions reports from industry working groups

  • Regulatory interactions

Acknowledgements

The organisers thank all speakers for their contributions, and to all participants for fruitful discussions. The authors acknowledge also the DMDG organising and technical team, in particular Stuart Hex and Chris Barron (AssociAction Enterprises), for support with organizing the workshop.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.