Renal Excretion of some Aryl Sulphate Esters in the Rat

Abstract

The renal clearance of inulin, phenyl [³⁵S]sulphate, naphthyl 2-[³⁵S]-sulphate and 2-hydroxy-5-nitrophenyl [³⁵S]sulphate was measured at various plasma concentrations in the rat.

A considerable proportion of each ester was bound to plasma proteins in vivo and the ratio of ³⁵S-labelled sulphate ester/inulin clearance demonstrated that all three esters are secreted by the renal cells.

The contribution of the renal secretory process to the overall urinary excretion ranged between 22–59% (phenyl [³⁵S]sulphate), 58–87% (naphthyl 2−[³⁵S]sulphate) and 60–72% (2-hydroxy-5-nitrophenyl [³⁵S]sulphate).

These findings are discussed in relation to the detoxication of phenols by sulphate conjugation.