Identification of the Major Metabolites of Propylhexedrine in vivo (in man) and in vitro (in guinea pig and rabbit)

K. K. Midha Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, SW3 6LX, UK

A. H. Beckett Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, SW3 6LX, UK

A. Saunders Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, SW3 6LX, UK

Abstract

Norpropylhexedrine, cyclohexylacetoxime, cis- and trans-4-hydroxypropylhexedrine were identified in the urine of man receiving propylhexedrine, by comparison with synthetic compounds on g.l.c. and by combined g.l.c.-mass spectrometry.

Incubation of the drug with hepatic preparations from rabbit and guinea-pig gave the above metabolic products and N-hydroxypropylhexedrine, N-hydroxy-norpropylhexedrine and cyclohexylacetone.

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Identification of the Major Metabolites of Propylhexedrine in vivo (in man) and in vitro (in guinea pig and rabbit)

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Identification of the Major Metabolites of Propylhexedrine in vivo (in man) and in vitro (in guinea pig and rabbit)

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