Induction and prevention of squamous transformation of bronchial epithelial cells by phenolic compounds

R. N. PALMATIER Department of Biochemistry,Alma College, 614 W. Superior, Alma,MI 48801, USA Department of Internal Medicine, Section of Pulmonary and Critical Care, University of Nebraska Medical Center, 600 S. 42nd Street, Omaha, NE 68198-5300, USA

T. HENRY Department of Biochemistry,Alma College, 614 W. Superior, Alma,MI 48801, USA Department of Internal Medicine, Section of Pulmonary and Critical Care, University of Nebraska Medical Center, 600 S. 42nd Street, Omaha, NE 68198-5300, USA

S. I. RENNARD Department of Biochemistry,Alma College, 614 W. Superior, Alma,MI 48801, USA Department of Internal Medicine, Section of Pulmonary and Critical Care, University of Nebraska Medical Center, 600 S. 42nd Street, Omaha, NE 68198-5300, USA

J. D. BECKMANN Department of Biochemistry,Alma College, 614 W. Superior, Alma,MI 48801, USA Department of Internal Medicine, Section of Pulmonary and Critical Care, University of Nebraska Medical Center, 600 S. 42nd Street, Omaha, NE 68198-5300, USA

Abstract

1. The exposure of cultured bovine bronchial epithelialcells to 2-naphthol and catechol (10-100 μM) induced a squamous phenotype and inhibited cell proliferation. Phenol and cresol did not have these effects at up to 100 μM. 2. These effects occurred below cytotoxic levels and cell proliferation resumed subsequent to removal of the exposures. 3. Induction of the squamous phenotype was antagonized by retinoic acid, a known morphogenic hormone for several airway epithelial cell culture model systems. 4. Purified recombinant bovine phenol sulphotransfera se was used to ablate the antiproliferative and squamous inductive effects of catechol on the cultured airway epithelial cells.

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Induction and prevention of squamous transformation of bronchial epithelial cells by phenolic compounds

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Induction and prevention of squamous transformation of bronchial epithelial cells by phenolic compounds

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