Synthesis and Polymerization of N-(2,4,5-trichlorophenyl) Acrylamide Monomer and its Thermal and Antimicrobial Properties

Abstract

N-(2,4,5-trichlorophenyl) acrylamide (CPAM) new monomer was synthesized by condensing acrylic acid and 2, 4, 5-tri chloro aniline using dicyclohexyl carbodiimide as a coupling agent. The CPAM monomer was characterized by ¹HNMR, FT-IR, and mass spectroscopy. Further, the CPAM monomer was homopolymerized by solution technique in toluene using azobisisobutyronitrile (AIBN) as an initiator. The CPAM monomer and its homopolymer were employed to screen an antimicrobial activity against E. coli, S. aureus, M. luteus, and B. subtilis microorganisms, which are representative of Gram-positive and Gram-negative bacteria using ciprofloxacin and Sulphametoxazol as standards. The results showed that the CPAM monomer has good antimicrobial activity, comparable with its homopolymer. Also, the CPAM homopolymer was investigated for its thermal stability by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC).

Keywords:

• antimicrobial activity
• n-(2,4,5-trichlorophenyl) acrylamide
• solution polymerization
• thermogravimetric analysis

Acknowledgments

The authors wish to thank UGC (SAP).