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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 60, 2011 - Issue 12
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Original Articles

Effect of Surface Modification of Nano-Hydroxyapatite Particles on In Vitro Biocompatibility of Poly (ϵ-Caprolactone)–Matrix Composite Biomaterials

C. Deng Leshan Institute of Silicon Materials, Leshan Normal University, Leshan, China; School of Materials Science and Engineering, Key Lab of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, Sichuan, ChinaCorrespondence[email protected]
,
X. Xiao Leshan Institute of Silicon Materials, Leshan Normal University, Leshan, China
,
N. Yao School of Materials Science and Engineering, Key Lab of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, Sichuan, China
,
X. B. Yang School of Materials Science and Engineering, Key Lab of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, Sichuan, China
&
J. Weng School of Materials Science and Engineering, Key Lab of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, Sichuan, China
Pages 969-978 | Received 01 Sep 2010, Accepted 01 Mar 2011, Published online: 08 Sep 2011
 
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Abstract

Three silane coupling agents were employed to modify the surfaces of nano-hydroxyapatite particles. Alamar Blue activity and alkaline phosphatase assay on the surfaces of the modified n-HA/PCL composites were carefully examined. The results showed that the KH792 silane modification had positively impact in interaction between bone marrow cells, and it suggested this KH792 modified composite was basically biocompatible with bone cells of rats.

Acknowledgments

This project was financially supported by the Scientific Research Fund of Leshan government (09GZD027) and Leshan University (Z1151).

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