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Abstract
Present research has been made to reduce frequency of administration and increase therapeutic efficacy by developing sustained release of diclofenac sodium. In this regard, prodrugs have been synthesized by using eco-friendly “green” materials such as cellulose and xylan by activation of carboxylic acid via N,N′-carbonyldiimidazole. The polymer–drug interactions were evaluated by means of FT-IR, powder X-ray diffraction, and thermal analysis techniques. In vitro release study of synthesized prodrugs might be suggested regarding protection of drug in the upper gastrointestinal tract, and, thereby, it is expected to reach the targeted site specifically to colon.
Acknowledgment
One of the authors, Mr. Samit Kumar, is highly thankful to the Ministry of Human Resource Development (MHRD), New Delhi, India, for the financial research grant for pursuing the PhD work. The authors are thankful to late professor Jugmendra Sain Upadhyaya for his valuable suggestions during the preparation of this research manuscript.
Notes
+ive, -ive, and +Δ signs indicate completely soluble, insoluble, and soluble after heating, respectively.
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