Characterization and In Vitro Evaluation of Freeze-Dried Nasal Insert Composed of Chlorpheniramine Maleate with Ionic and Nonionic Polymer for Intranasal Delivery

Abstract

In this study, the authors report the fabrication of nasal delivery system, termed nasal insert, and was carried out with ionic and nonionic polymer(s). The data revealed that nonionic polymer has less water uptake and low mucoadhesion time in comparison to the ionic polymers. With ionic polymers, relaxation of entangled polymer from the gel was toward lesser extent, thereby providing sustained release during in vitro release. The SEM images show more compact nature of ionic polymer when compared with nonionic polymer. Histopathology and in vitro permeation study conducted using sheep nasal mucosa showed significantly higher drug permeation from nonionic polymer.

Keywords:

• Chlorpheniramine maleate
• ionic polymers
• nasal delivery
• nasal insert
• nonionic polymer

Notes

Note. Amount of drug used in all the formulation was 100 mg.

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