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Abstract
A modified nanofibrous poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nerve conduit has been used to evaluate its efficiency based on the promotion of peripheral nerve regeneration in rats. The authors used a gelatin-modified nanofibrous poly (3-hydroxybutyrate-co-3-hydroxyvalerate) nerve conduit to bridge a 30 mm long gap in the rat sciatic nerve. At four months after nerve conduit implantation, regenerated nerves were macroscopically observed and histologically assessed. In the nanofibrous graft, the rat sciatic nerve trunk had been reconstructed by restoration of nerve continuity and formation of myelinated nerve fiber. There were Schwann cells and glial cells in the regenerated nerves. These findings suggest that modified nanofibrous poly(3-hydroxybutyrate-co-3- hydroxyvalerate) nerve conduit is suitable for repair of long-segment sciatic nerve defects.
Acknowledgment
The authors would also like to thank Dr. Abdolaziz Ronaghi and Dr. Jafar Doostmohamadpour (neuroscience research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran) for their assistance in surgical procedure.
Notes
The data are presented as mean ± SD (n = 5), p < 0.05.
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