Polylactide (PLA)-Based Electrospun Fibrous Materials Containing Ionic Drugs as Wound Dressing Materials: A Review

Abstract

The effect of the electrospinning process parameters on the morphology, alignment, and self-organization of the fibers into bundles and/or yarns are outlined. The fabrication of polylactide materials containing ionic drugs by electrospinning is emphasized. The main approaches used for the preparation of electrospun drug-loaded materials: electrospinning of a mixed solution containing the polymer(s) and the drug(s) or dual spinneret electrospinning of separate drug-containing solutions are compared. The latter approach allows the obtaining of drug-loaded fibrous materials while avoiding the drug interaction. The potential application of the obtained materials containing ionic drugs as wound dressings is outlined.

Keywords:

• Electrospinning
• ionic drug
• microfibers
• nanofibers
• poly(lactic acid)
• polylactide
• wound dressing

Notes

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