Preliminary Study for Vascular Tissue Engineering by Electrospinning Angelica Polysaccharide (ASP)/PLA Microfibrous Scaffolds

Abstract

The purpose of this investigation was to develop the feasibility of utilizing Angelica polysaccharide in vascular tissue engineering area. Angelica polysaccharide and poly lactic acid (PLA) microfibrous mixed in different ratios were prepared with electrospinning apparatus. A series of detection technology (SEC-LLS, SEM, MTT, paraffin sections, mechanical test) was used to characterize and determine the property of composite scaffold such as molecular weight, biomechanical, bioactivity, cytotoxicity, biocompatibility, and biodegradability. The scaffolds exhibited similar mechanical property to the native tissues, possessed good biological compatibility and decreased platelet adhesion/aggregation rate. All these showed the excellent potentiality of Angelica polysaccharide in vascular tissue engineering.

Keywords:

• Angelica polysaccharide
• electrospinning
• microfibrous scaffolds
• vascular tissue engineering

Acknowledgments

Zhang Weijie and Hua Dawei contributed equally to this article.

Notes

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