Radioiodinated Magnetic Nanoparticles Conjugated With Moxifloxacin: Synthesis and In Vitro Biological Affinities

Ozge Kozgus Guldu Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, Bornova, Izmir, Turkey

Perihan Unak Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, Bornova, Izmir, TurkeyCorrespondence[email protected]

E. Ilker Medine Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, Bornova, Izmir, Turkey

F. Baris Barlas Department of Biochemistry, Faculty of Sciences, Ege University, Bornova, Izmir, Turkey

F. Zumrut Biber Muftuler Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, Bornova, Izmir, Turkey

Suna Timur Department of Biochemistry, Faculty of Sciences, Ege University, Bornova, Izmir, Turkey; Institute of Drug Abuse Toxicology & Pharmaceutical Sciences, Ege University, Bornova, Izmir, Turkey

Abstract

Magnetic nanoparticles (MNPs) were synthesized and coated with tetraethyl orthosilicate and aminosilane to create functional amino groups. Moxifloxacin (MXF) was conjugated to the modified MNPs using glutaraldehyde as crosslinker. Finally, MXF conjugated magnetic nanoparticles were radiolabeled and their biological affinities such as cell incorporation ratio, cytotoxicity, and their potential as cell imaging probe were investigated using A-549 cells.

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Radioiodinated Magnetic Nanoparticles Conjugated With Moxifloxacin: Synthesis and In Vitro Biological Affinities

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Radioiodinated Magnetic Nanoparticles Conjugated With Moxifloxacin: Synthesis and In Vitro Biological Affinities

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