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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 66, 2017 - Issue 2
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Original Articles

Succinyl pullulan-crosslinked carboxymethyl chitosan sponges for potential wound dressing

Xin WangEngineering Research Center for Biomedical Materials, School of Life Science, Anhui University, Hefei, P. R. China
,
Di ZhangSchool of Pharmaceutical Science, Jiangnan University, Wuxi, P. R. China
,
Jun WangEngineering Research Center for Biomedical Materials, School of Life Science, Anhui University, Hefei, P. R. China
,
Rupei TangEngineering Research Center for Biomedical Materials, School of Life Science, Anhui University, Hefei, P. R. ChinaCorrespondence[email protected]
,
Bing WeiEngineering Research Center for Biomedical Materials, School of Life Science, Anhui University, Hefei, P. R. China
&
Qiong JiangEngineering Research Center for Biomedical Materials, School of Life Science, Anhui University, Hefei, P. R. China
Pages 61-70 | Received 03 Dec 2015, Accepted 22 Apr 2016, Published online: 11 May 2016
 
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ABSTRACT

The crosslinked succinyl pullulan-carboxymethyl chitosan composite sponges (Pullulan-CMCS) were fabricated for potential wound dressing. The structure and micromorphology of Pullulan-CMCS sponges were investigated by FTIR spectroscopy and SEM. Pullulan-CMCS sponges had lots of porous structures, making it absorb much liquid and quickly reach swelling equilibrium. WVTR results showed that Pullulan-CMCS sponges can reduce the accumulation of wound exudates in a certain degree. Biocompatibility test showed these sponges had no cytotoxicity or hemolytic potential. In vivo experiments demonstrated that Pullulan-CMCS sponges can effectively heal full-layer wound of skin defects of male ICR mice with accelerated fibroblast proliferation and enhanced epithelial migration.

GRAPHICAL ABSTRACT

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