Effect of thermal-responsive surfaces based on PNIPAAm on cell adsorption/desorption

Jiajie BiState Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, China

Kedong SongState Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, ChinaCorrespondence[email protected]

Suli WuState Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, China

Yu ZhangState Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, China

Yiwei WangBurns Research Group, ANZAC Research Institute, University of Sydney, Concord, New South Wales, Australia

Tianqing LiuState Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, China

ABSTRACT

Due to the availability and timeliness of autologous cells, the in vitro cultivation and expansion of cells in large scale is very necessary before clinical treatments. However, traditional cell-harvesting methods including machinery scraper and enzymatic method would produce irreversible damage for treated cells. The appearance of intelligent temperature-responsive cell culture surfaces can solve the problem. Therefore this review focuses on the development of temperature-responsive surfaces based on poly(N-isopropylacrylamide) in recent years and the impact on cell adsorption and desorption processes.

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Acknowledgments

ADSCs transfected with BMP-2 (P4) were provided as a gift by Dr. Xinjian Qu at our laboratory.

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Effect of thermal-responsive surfaces based on PNIPAAm on cell adsorption/desorption

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Effect of thermal-responsive surfaces based on PNIPAAm on cell adsorption/desorption

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