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ABSTRACT
Hydrophobic modified alginate (HM-alginate) has been synthesized by derivatization of sodium alginate (SA) with dodecyl glycidyl ether (DGE) in an aqueous solution. Using orthogonal optimization methods, the optimum combined parameters were explored as follows: 75°C, 70 mL H2O, 0.20 mmol sodium dodecyl sulfate and 2.0 mL DGE (mole ratio of SA to DGE, 2.2:1), the maximum yield was 112.62%. Their micellar properties and rheological properties were investigated, respectively. In addition, their drug delivery behaviors were evaluated with Sudan IV as a hydrophobic model drug.
GRAPHICAL ABSTRACT
Additional information
Funding
This research was supported by the National Natural Science Foundation of China (No. 20876081), the Natural Science Foundation of Shandong Province (ZR2012BM015).