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ABSTRACT
Chitosan–silver nanocomposites (CS-HDA-AgNCs) was prepared using chitosan, biogenic silver nanocomposites, and crosslinker, hexamethylene 1,6-di(amino carboxysulfonate) (HDA). The film is flexible and transparent. Its physical, mechanical, thermal, hydrophilicity, and swelling properties were improved by HDA (2.5%). The antimicrobial activity of CS-HDA-AgNCs were not displayed any remarkable zone of inhibition but showed toxic effect in the presence of normal 3T3 fibroblasts and cancer HeLa cells. It decreases to ca. 5–7% for both cell lines. In conclusion, it can be mentioned that the CS-HDA-AgNCs, a kind of new functional biomaterial, could be useful for health-care applications.
GRAPHICAL ABSTRACT
Additional information
Funding
The authors are grateful to the Ministry of Education, Youth and Sports of the Czech Republic - NPU Program I (LO1504) and Slovak Grant Agency VEGA for the financial support in the project 2/0156/15. The authors are also thankful to the Department of Material Science and Nanotechnology (IISc) Bangalore, India, for TEM analysis.