Soy flour–ZnO nanoparticles for controlled release of silibinin: Effect of ZnO nanoparticle, surfactant, and cross-linker

ABSTRACT

Silibinin-loaded soy flour–zinc oxide nanoparticle (ZnO) nanoparticles were prepared and characterized by different techniques. The average particle size and zeta potential value of the nanoparticles were found in the range 10–15 nm and −29.88 to −40.85 mV, respectively. The effects of ZnO nanoparticle, surfactant, and cross-linker were evaluated with regard to swelling, encapsulation efficiency, and drug release in different pH medium. Both swelling degree (%) and cumulative release (%) were better in pH 7.4 and maximum cumulative release (%) was 50%. Cytotoxicity study was performed by MTT assay using normal human blood and MDA-MB-435S cancer cell lines.

GRAPHICAL ABSTRACT

KEYWORDS:

• Genipin
• silibinin
• soy flour

Acknowledgment

Authors would like to acknowledge UGC for the financial support as Institutional Fellowship.