Evaluation of acrylic bone cements with single and combined antibiotics: Release behavior and in vitro antibacterial effectiveness

ABSTRACT

This work studied the eluting behavior of ciprofloxacin, meropenem, and ceftazidime (and their mixtures) with that of gentamicin from antibiotic-loaded bone cements (ALBCs). In vitro release was followed by UV–Vis for 30 days and a semiempirical eluting model that considers the processes of dissolution and diffusion were proposed: . The antimicrobial efficacy against Pseudomonas aeruginosa and Staphylococcus aureus of the prepared ALBCs was also evaluated. The results showed that the amount of antibiotic released increased when ciprofloxacin/meropenem or ciprofloxacin/ceftazidime was used and that their antibacterial inhibitory effect against microorganisms tested was improved as a consequence of the synergistic effect.

GRAPHICAL ABSTRACT

KEYWORDS:

• Antibiotic-loaded bone cement
• local antibiotic therapy
• osteomyelitis
• prosthesis infection

Contributions of authors

LMA: Research promoter, UV–Vis and microbiological tests, data analysis and writing of the paper. APMR: Microbiological tests, data analysis, and writing of the paper. JAMF, DLRH, ORG, OELL: Microbiological tests and data analysis. JADGM, GFE: UV-Vis tests, data analysis, and writing of the paper.

Additional information

Funding

Lizette Morejón Alonso acknowledges the financial support from the University of Guadalajara (UDG), Mexico, especially to the Electronic Department (Degree in Biomedical Engineering). This work is not associated with any scientific or financial conflicts of interest.