ABSTRACT
To reduce the side effects of ibuprofen caused by prolonged or overdosed treatment on the human body, a series of thermosensitive poly(N,N′-methylene bisacrylamide-co-N-isopropylacrylamide) microcapsules were synthesized to control the release of ibuprofen by their thermosensitive properties. The release curves exhibited excellent controllable behavior, which turned from burst release to perfect sustained release by changing the ambient temperature from 25°C (<LCST, lower critical solution temperatures) to 37°C (>LCST). In addition, the NIPAm content and the shell thickness can be conveniently controlled during the polymerization processes, which will affect the drug release rate according to the temperature stimuli.
GRAPHICAL ABSTRACT
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