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Abstract
In an effort to reduce the dose of drugs and in order to improve drug efficacy, avermectin (AVM) was encapsulated by amphipathic polyacrylic ester (PAE) via self-assembly. The experimental results indicated that the AVM/PAE nanoparticles were spherical in shape, homogeneous dispersion, and had a core-shell structure, the particle size ranged from 172.7 nm to 337.8 nm, the highest encapsulation efficiency and loading capacity were 62.11 and 25.65%. The anti-UV property has been significantly improved. Consistent with the Korsmeyer–Peppas model, the release rate was observed to be higher upon decreasing Tg and increasing the core-shell ratio.
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Funding
This research was supported by National Natural Science Foundation of China [Grant No. 21576303, 21606262], Science and Technology Program of Guangzhou, China [Grant No. 201604020054, 201707010473], Ordinary University Innovation Project of Guangdong Province [Grant No. 2016KTSCX062].