Electrospun polycaprolactone/gelatin/bioactive glass nanoscaffold for bone tissue engineering

Abstract

Polycaprolactone scaffolds, polycaprolactone/gelatin, and polycaprolactone/gelatin/bioactive glass scaffolds were prepared with ratios of 50/50, 25/75, and 75/25 for polymers and 5 wt% for the bioactive glass via electrospinning and then were characterized using. The results indicated that by adding gelatin and bioactive glass to polycaprolactone scaffold, the diameter of fiber decreased from 557 to 167 nm. The results showed growth of apatite layer on the scaffolds after immersion in simulated body fluid for 28 days. The results of mechanical test revealed that by adding bioactive glass to scaffolds, the ultimate tensile strength and Young's modulus increase about two folds.

Graphical Abstract

Keywords:

• Bioactivity
• bone tissue engineering
• degradation behavior
• electrospun scaffold
• mechanical properties
• nanocomposite