Preparation and characterization of lysine-modified polylactic acid microspheres

Abstract

Lysine-modified polylactic acid microspheres were prepared by ammonolysis combined with emulsification and thermally induced phase separation technique. Lysine molecules have been successfully grafted onto the molecular chain of polylactic acid microspheres. The microspheres prepared under the optimum reaction condition have a desired homogeneous nanofibrous structure and improved hydrophilicity. Amino-modified polylactic acid nanofibre microspheres with a high porosity, large specific surface area, strong adsorption capacity, and rich in active amino groups were prepared for drug delivery applications by aminolysis combined with emulsion and thermally induced phase separation technique from a ternary ethylenediamine aqueous solution/PLLA-dioxane/propanetriol system.

GRAPHICAL ABSTRACT

Keywords:

• Bioactivity
• lysine
• modification
• nanofibrous structure
• polylactic acid microspheres

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China [Grant 21805037], Fujian Province Nature Science Foundation [Grants 2016Y0025, 2017J01685] and Fuzhou Science and Technology Project [Grants 2017-G-61, 2018-G-90].