Gelatin-based mucoadhesive membranes containing inclusion complex of thymol/β-cyclodextrin for treatment of oral infections

Abstract

Oral infections are associated with the appearance of systemic diseases. Among the natural products, commercially used in dental formulations is thymol (TM). However, this compound presents low stability. In order to overcome these limitations, the membranes were prepared using the solvent evaporation method and TM/β-cyclodextrin using the liofilization technique. The results showed that the presence of inclusion complex in the membranes causes considerable modifications in the physical-chemical, morphological, and mucoadhesive properties. In addition, the membranes presented antimicrobial activity. These data show that mucoadhesive membranes containing IC may be promising systems for TM delivery in the treatment of oral infections.

Graphical Abstract

ABBREVIATIONS

β-CD: β-cyclodextrin, TM: Thymol, IC: Inclusion complex, XRD: X-ray diffraction, ATR-FTIR: Attenuated Total Reflectance-Fourier Transform Infrared, SEM: Scanning electron microscopy, DSC: Differential Scanning Calorimetry, TG: Thermogravimetry, Propylene glycol (PPG).

Keywords:

• Gelatin
• inclusion complex
• mucoadhesive
• oral infections
• thymol

Acknowledgments

The authors are grateful to Instituto de tecnologia e pesquisa - ITP and University of Sorocaba - Uniso for performing out the tests.

Disclosure statement

The authors declare that there is no conflict of interests regarding the publication of this paper. The raw/processed data required to reproduce these findings cannot be shared at this time as the data also forms part of an ongoing study.

Data availability

The raw/processed data required to reproduce these findings cannot be shared at this time as the data also forms part of an ongoing study.

Additional information

Funding

The authors are grateful to National Council for Scientific and Technological Development - CNPq and Fundação de Amparo a Pesquisa do Estado de Sergipe -FAPITEC-SE for the financial support.

The authors are grateful to National Council for Scientific and Technological Development - CNPq and Fundação de Amparo a Pesquisa do Estado de Sergipe -FAPITEC-SE for the financial support.