Natural collagen bioscaffolds for skin tissue engineering strategies in burns: a critical review

Abstract

Global strategies on burn management have brought significant reduction in burn associated infections and morbidity. Yet, full regeneration of the damaged skin tissue is a formidable challenge despite improvements in health and safety standards. Nevertheless, it becomes an unmet clinical need of the hour to search for improved functional remedies. This critical review highlights the relevance of skin tissue engineering strategies for natural biomimetic burn scaffolds, their various sources and possible scaffolding technologies. Collagen biopolymer with its regenerative, biocompatible, nontoxic, cost effective, and local availability attributes to the biomaterial of choice for addressing skin burns.

Graphical Abstract

Keywords:

• Burn wounds
• collagen
• scaffold
• tissue engineering

Acknowledgements

The first author is thankful to University of Kerala for providing infrastructure facility for carrying out this work.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The first author is thankful to University Grants Commission – Junior Research Fellowship (UGC-JRF), New Delhi for the financial support.