Synthesis and characterization of metformin-pluronic based polyurethanes for controlled drug delivery

Abstract

Segmented polyurethanes (SPU) were synthesized with Pluronic F127 (PLU) as soft segment and 4,4′-methylene-bis(cyclohexyl) diisocyanate (HMDI) and Metformin (Met) as rigid segment (HMDI-Met) while antidiabetic content increased by using 20%, 30%, 40%, and 50% of rigid segments. The Met incorporation was provided by FTIR, Raman, NMR, and XPS. By increasing the content of rigid segments, the first decomposition temperature tends to increase from 317 °C to 361 °C while T_g was modified from −80 °C to −50 °C. Mass loss was observed during accelerated degradation and therefore SPU-PLU-Met can deliver up to 40 µg/30 days of Met. Cytotoxicity test showed no deleterious effect.

GRAPHICAL ABSTRACT

KEYWORD:

• Segmented polyurethane
• metformin
• biocompatibility

Acknowledgments

Bonilla-Hernández thanks to CONACyT (Grants 402793 and 28672). The authors also want to thank Patricia Quintana and Daniel Aguilar Treviño for XRD and Willian Cauich for XPS experiments at Laboratorio Nacional de Nano y Biomateriales (LANBIO), Cinvestav-IPN, Unidad Mérida (Projects FOMIX-Yucatan 2008-108160 and CONACyT LAB-2009-01 no. 123913). Finally, we thank CONACYT 268595 for the use of Raman facilities.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the Consejo Nacional de Ciencia y Tecnología (CONACYT-Mexico) Projects 248378 (Atención a Problemas Nacionales) and 1360 (Fronteras de la Ciencia).