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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 71, 2022 - Issue 2
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Preparation of poly(cyclotriphosphazene-co-piperazine) nanospheres and their drug release behavior

Sahid MehmoodState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China
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Li WangState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9356-9930
ORCID Icon,
Haojie YuState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. ChinaCorrespondence[email protected]
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Fazal HaqState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China
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Bilal-ul AminState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China
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Md Alim UddinState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China
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Shah FahadState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China
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Muhammad HaroonState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China
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Di ShenState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China
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Zhipeng NiState Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China
 show all
Pages 139-147 | Received 29 Jun 2020, Accepted 10 Aug 2020, Published online: 23 Aug 2020
 
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Abstract

In this study, poly(cyclotriphosphazene-co-piperazine) p(HCCP-co-PIP) nanospheres were prepared. The successful preparation of the p(HCCP-co-PIP) nanospheres was confirmed by FT-IR, SEM, TEM, XRD, TGA and DLS, respectively. The prepared p(HCCP-co-PIP) nanospheres were used for drug delivery system. The model drug doxorubicin (DOX) was loaded in p(HCCP-co-PIP) nanospheres. The drug release properties of the p(HCCP-co-PIP) nanospheres were investigated in pH 4.0 and pH 7.4. The cumulative release was found to be 86.2% in pH 4.0 and 54.7% in pH 7.4 at 37 °C after 216 h. The obtained result suggested that the nanospheres could be used as drug carriers.

Graphical Abstract

Disclosure statement

The authors declare that they have no conflict of interest.

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