Recent advances in surface modification of biopolymeric nanofibrous scaffolds

Abstract

Nanofibrous biomaterials, because of their structural similarity to the extracellular matrix, can be employed as a scaffold in tissue engineering. The use of biopolymers to nanofibers fabrication attracts a great deal of attention. However, sometimes these nanofibers do not support specific cell behaviors. To address this drawback, surface modification of these structures has been actively investigated. Just a while ago, nanofibrous scaffolds have been modified employing various techniques to provide an appropriate microenvironment for protecting cell functions. Modification of bulk or surfaces of the nanofibrous scaffolds via different methods can promote cell adhesion, growth, proliferation, migration, and differentiation. In this paper, we are going to discuss the different and new approaches to surface modification of polymeric nanofibers that can influence scaffolds characteristics.

GRAPHICAL ABSTRACT

Surface modification of nanofibrous scaffolds can improve physical & chemical properties especially cellular behaviors.

Keywords:

• Cell behaviors
• nanofiber
• scaffolds
• surface modification
• tissue engineering

Disclosure statement

The authors have no conflicts of interest to report in this work. The authors alone are responsible for the content and writing of the paper.