Fabrication of a molecular imprinted composite and its application in the measurement of ceftriaxone in an electrochemical sensor

Abstract

The use of voltammetry to measure drugs is a privilege because of their high accuracy, speed, and low cost. Molecular imprinted polymer (MIP) made with methacrylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) was used to modify the glassy carbon electrode and polydiphenylamine (PDPA) was synthesized by electropolymerization method as an immobilizer. Underneath this polymeric layer, there was a layer of reduced graphene oxide (RGO) which was electrochemically synthesized by applying a constant potential to increase the sensitivity of the electrode. The designed electrode was used after several optimization steps to measure trace amounts of ceftriaxone. A linear range was found between 0.025 and 3.047 µM and a detection limit of 0.008 µM.

GRAPHICAL ABSTRACT

Keywords:

• Ceftriaxone
• electropolymerization
• molecular imprinted polymer
• reduced graphene oxide
• voltammetry

Disclosure statement

All the authors of this article declare that they have no conflict of interest.

Additional information

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.