Preparation of poly(acrylamide-co-Acrylonitrile) thermosensitivity microgel and control release of aspirin

Abstract

To extend the release time of drug carriers with the thermoresponsive behavior of upper critical solution temperature (UCST), P(AAm-co-AN) microgels are prepared by precipitation polymerization. It is found that the microgels exhibit the UCST-type response and the microgel shows swelling and disperses well when the temperature is higher than the critical temperature. Because the microgel can swell and shrink reversibly with the change in solution temperature, it can be used as a drug carrier. Compared with the micellar carrier, the microgel carrier’s structure is more stable and has a better sustained-release effect.

Graphical Abstract

Keywords:

• Drug loading and releasing
• thermosensitivity microgel
• upper critical solution temperature (UCST)

Acknowledgments

We gratefully acknowledge the financial support provided by the National Natural Science Foundation (No. 52073239).

Disclosure statement

The authors declare no competing financial interest.