Dendrimer as nanocarrier for drug delivery and drug targeting therapeutics: a fundamental to advanced systematic review

Abstract

Development of novel nano therapeutic material is of great interest among the researchers and with continuous advancement in nanotechnology, dendrimer a monodispersed unimicellar nanosize drug carrier with spacious globular 3D architecture in which the drug can be encapsulated is widely explored. This encapsulation of drug improves its pharmacokinetic and pharmacodynamics properties and more importantly enhances their bioavailability. A dendrimer based drug delivery system is a boon in targeted drug delivery. Its applications are not restricted to the pharmaceutical or medical field but also in other fields of science. The presence of various functional groups on the periphery has made their surface modifiable with therapeutic drugs, diagnostic agents, and targeting ligands. The vast surface area shows its capability to be used as a catalyst in chemical reactions too. And its biocompatibility makes its use much more effective and safer than other nano-carriers. This review tries to give a comprehensive description of this nano therapeutic, its properties, characteristics, method of synthesis, pharmacokinetics, toxicity, and recent applications in various fields, which can help the researchers for producing more promising outcomes of the dendrimers.

Graphical Abstract

Keywords:

• Bioactive nanocarrier
• dendrimer
• encapsulation
• PAMAM
• targeted drug delivery

Acknowledgments

The authors express their sincere thanks to the Honorable Chancellor and Vice-Chancellor of Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India, for their constant encouragement to carry out this work and also for providing necessary facilities for the same.

Disclosure statement

The authors declare no conflict of interest.