Pharmacological agents causing sexual dysfunction

Abstract

Reports of pharmacological agents affecting the human sexual response cycle are critically reviewed. Because of the paucity of adequately designed studies, few definitive statements can be made about pharmacological effects on human sexual functioning. Tentative evidence suggests that drugs with side effects of adrenergic blockade are associated with ejaculatory disturbances. Impotence appears to be associated with drugs possessing significant anticholinergic activity. Drug induced impotence and retarded ejaculation could both also be related to central dopamine blockade.