Low-Dose imipramine for thioridazineinduced male orgasmic disorder

Abstract

Male orgasmic disorder is commonly encountered among patients treated with thioridazine. This side effect intqferes significantly with sexual satisfaction. In this pilot study, eight male schizophrenic patients who complained of orgasmic disorder, compatible with probable retre grade ejaculation during thioridazine treatment, were given concomitant low-dose imipamine (25–50 mg at bedtime). Four of the eight reported complete resumption of their pmious ejaculat9 function, and in one patient there was a partial, but substantial, improvement. Three patients noted no change. It appears that imipamine might be beneficia1 for some patients with thioridazine-induced male orgasmic disorder.