Action of Mercuric Acetate on Pyridazine Derivatives

Abstract

4,6-Disubstituted pyridazin-3(2H)-ones react with mercuric acetate in polar solvent to give mercurated products. The mercuration reactions took place on the active methylene group. The reaction with 4,5-dihydro-6-phenyl- and p-tolyl-, pyridazin-3(2H)-one gives the corresponding dimer via two steps: 1) mercuration reaction on position 4 to form mercuri-bis-compounds followed by 2) demercuration. Mercuration of 4,5-dihydro-6-methylpyridazin-3(2H)-one took place in position 4 to give monomercurated product. The structures are supported by elemental analysis, IR, and ¹H n.m.r. spectra.