Synthesis of Organophosphorus Compounds Used to Obtain Antibodies Against Nerve Agent VX

G. Rima Laboratoire de Chimie des Organominéaux, URA n° 477 CNRS, Université Paul Sabatier, 118 route de Narbonne, 31062, Toulouse, Cedex, France

J. Satgé Laboratoire de Chimie des Organominéaux, URA n° 477 CNRS, Université Paul Sabatier, 118 route de Narbonne, 31062, Toulouse, Cedex, France

C. Pradel Laboratoire de Chimie des Organominéaux, URA n° 477 CNRS, Université Paul Sabatier, 118 route de Narbonne, 31062, Toulouse, Cedex, France

J. M. Grognet Service de Pharmacologic et d'Immunologie, C. E./ Saclay, 91991, Gif sur Yvette, Cedex, France

M. Istin Service de Pharmacologic et d'Immunologie, C. E./ Saclay, 91991, Gif sur Yvette, Cedex, France

H. Sentenac-Roumanou Direction des Recherches Etudes et Techniques, 26 Bd Victor, 00460, Paris, Armées

C. Lion Direction des Recherches Etudes et Techniques, 26 Bd Victor, 00460, Paris, Armées

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Abstract

New organophosphorus compounds utilized as haptens in immunology against organophosphorus compounds, inhibitors of acetylcholinesterase, have been synthesized. These compounds have structures similar to that of the organophosphorus nerve agent VX : [O-ethyl S-(2-(diisopropylamino)ethyl)methylphosphonothioate]

by substitution of the S-atom by an O-atom or CH₂ group, and by introduction of aryl, alkyl or alkylaryl groups instead of an ethyl group.

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Synthesis of Organophosphorus Compounds Used to Obtain Antibodies Against Nerve Agent VX

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Synthesis of Organophosphorus Compounds Used to Obtain Antibodies Against Nerve Agent VX

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