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Original Articles

Synthesis of Organophosphorus Compounds Used to Obtain Antibodies Against Nerve Agent VX

, , , , , & show all
Pages 277-288 | Received 05 Nov 1991, Accepted 27 Nov 1991, Published online: 22 Nov 2011
 

Abstract

New organophosphorus compounds utilized as haptens in immunology against organophosphorus compounds, inhibitors of acetylcholinesterase, have been synthesized. These compounds have structures similar to that of the organophosphorus nerve agent VX : [O-ethyl S-(2-(diisopropylamino)ethyl)methylphosphonothioate]

by substitution of the S-atom by an O-atom or CH2 group, and by introduction of aryl, alkyl or alkylaryl groups instead of an ethyl group.

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