Synthesis, Characterization and Cytotoxicity of New Complexes of Cobalt(III), Nickel(II) and Copper(II) with Quinoxaline-2-carboxaldehyde Thiosemicarbazone

Abstract

New quinoxaline-2-carboxaldehyde thiosemicarbazone (H-QTSC) complexes of cobalt(III), nickel(II) and copper(II) have been prepared and characterized on the basis of elemental analyses, molar conductance, magnetic susceptibility, and electronic and infrared spectral data. Analytical and molar conductance data suggest that the complexes have the formulae [Co(QTSC)₂IX, [Ni(H-QTSC)₂(OAc)X] and [Cu(QTSC) (OAc) (H₂O)]₂ (where X = Cl or Br and OAc = acetate). The magnetic and spectral data suggest a distorted octahedral geometry for the complexes. The copper complex appears to be dimeric with bridging acetate groups. The ligand acts as a uninegative tridentate NNS donor in the cobalt and copper complexes, while it acts as a neutral bidentate NS donor in the nickel complexes. The cytotoxicity of the cobalt(III) complexes were determined in vitro as well as in tissue culture. The chloro complex was found to have greater cytotoxic activity than the bromo complex.

Referee I: G. Dyer

Referee II: A. Pidcock

Notes

Referee I: G. Dyer

Referee II: A. Pidcock